Research
Learn About What We're Working On
Learn About What We're Working On
Changes in neural circuit activity play a critical role in many aspects of nervous system function throughout life, from development to learning and the progression of disease. We study how neural circuits of the mouse neocortex encode the sensory environment, and how the rules of encoding undergo plasticity during altered sensory experience. We use chronic in vivo imaging techniques to measure functional changes of both large-scale activity maps and the underlying local neuronal populations. Two-photon imaging of neurons expressing genetically encoded activity sensors allows us to repeatedly measure activity of the exact same neurons over days and weeks as plasticity takes place. Defining the logic of functional plasticity within cortical circuits has implications for understanding how the brain changes under pathological conditions and for identifying cellular targets to enhance functional recovery.
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